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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ADORA2A

contributors: mct/npt/pgu - updated : 12-02-2013

HGNC name	adenosine A2a receptor
HGNC id	263

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function selective inactivation of ADORA2A in striatal neurons enhances working memory and reversal learning (

Susceptibility

to modification of age at onset in Huntington's disease to habitual caffeine consumption

Variant & Polymorphism other	rs5751876 T/T genotype have an earlier age at onset of 3.8 years as compared to C/C genotype
	probability of having the ADORA2A 1083TT genotype decreases as habitual caffeine consumption increases

Candidate gene
Marker	its expression in peripheral blood mononuclear cells may be a valuable means of differentiating amnestic mild cognitive impairment and multiple cognitive domain mild cognitive impairment
Therapy target
	System Type Disorder Pubmed dermatology skin   pharmacological A2AR blockade can be used to diminish scarring while improving the collagen composition and tensile strength of the healed wound neurology neurodegenerative huntington chorea novel therapeutic pathway of A2A receptor in HD and further strengthen the concept that the ADORA2A can be a drug target in treating HD

ANIMAL & CELL MODELS