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FLASH GENE
Symbol VIPR1 contributors: mct - updated : 23-09-2011
HGNC name vasoactive intestinal peptide receptor 1
HGNC id 12694
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • N-terminal ectodomain with a major VIP-binding site
    • HOMOLOGY
    Homologene
    FAMILY
  • secretin receptor superfamily, G protein coupled
    • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • localized in cell nuclear fraction
    • basic FUNCTION
  • involved in the regulation of important biological functions
  • dual role for VIPR1 and VIPR2 receptors in mediating the antiproliferative effects of VIP with VIPR2 appearing to play a more dominant role
  • VIP and its receptors (VIPR1, VIPR2) are involved in proliferation, survival, and differentiation in human breast cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coupling with Gs alpha protein and activating adenylate cyclase
  • receptor for VIP
  • binding to HIV-1 (facilitating its productive infection)
  • interaction with VIP and VIPR2 (expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VIPR2 receptors or directs them toward a neuronal fate via VIPR1 receptors)
    • cell & other
    REGULATION
    Other regulated by short promoter,during enterocytic differentiation of the cancer cell line CaCa-2CL20
    activity of this receptor is mediated by G proteins which
    activate adenylyl cyclase
    regulated by NR1H4 agonists in the gallbladder epithelium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer as compared to non-tumor tissue (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS