Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol COL8A1 contributors: mct - updated : 03-09-2010
HGNC name collagen, type VIII, alpha 1
HGNC id 2215
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skin/Tegumentskin    
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • network forming collagen with a GLy-X-Y repeat sequence interspersed by small interruptions
  • a C1Q domain
    • conjugated GlycoP
    mono polymer homomer , heteromer , trimer
    HOMOLOGY
    interspecies ortholog to murine Col8a1 (87 pc)
    Homologene
    FAMILY
  • collagen family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text vascular subendothelial matrices
    basic FUNCTION
  • play a central role in maintaining the integrity and stability of the undiseased as well as of the atherosclerotic vessel wall
  • structure of cornea
  • may be playing an essential role for notochord morphogenesis (Gansner 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of Descemet membrane (posterior lining membrane of cornea)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS