| basic FUNCTION
| stimulating DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, synthesis of hyaluronic acid and sulfated glycosaminoglycan and the formation and secretion of plasminogen activator by human synovial cells |
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being a potent chemoattractant and activator for neutrophils |
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stimulates the priming of osteoclast progenitors for differentiation into osteoclasts (Nakao 2009) |
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has the potential to induce inflammatory responses within the atherosclerotic plaque (Smith 2006) |
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may be playing a role to limit platelet-activating factor -dependent vascular tissue damage by preventing degranulation of neutrophils without affecting their migration into the inflamed tissue (Schwartzkopff 2002) |
