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FLASH GENE

Symbol

PPBP

contributors: mct/npt - updated : 08-04-2009

HGNC name	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
HGNC id	9240

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.14 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - IL8 - CXCL1 /PPBP /PF4 - CXCL5 /CXCL6 - CXCL2 /CXCL3 - CXCL11 - CXCL10 - CXCL9 - qter
Authors	O'Donovan (99)
Text	see IMC2@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PPBP 3 - 715 10.27 128 - Smith (2006)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Reproductive female system placenta

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic megakaryocyte Blood/Hematopoietic platelet

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY

intercrine alpha family (small cytokine CXC)

CATEGORY

secretory , signaling cytokine growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	stimulating DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, synthesis of hyaluronic acid and sulfated glycosaminoglycan and the formation and secretion of plasminogen activator by human synovial cells
	being a potent chemoattractant and activator for neutrophils
	stimulates the priming of osteoclast progenitors for differentiation into osteoclasts (Nakao 2009)
	has the potential to induce inflammatory responses within the atherosclerotic plaque (Smith 2006)
	may be playing a role to limit platelet-activating factor -dependent vascular tissue damage by preventing degranulation of neutrophils without affecting their migration into the inflamed tissue (Schwartzkopff 2002)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

text	glucose transporter
	blood clotting

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with IGF2 (has the ability to strongly stimulate osteoclastogenesis by regulating PPBP expression in stromal cells and SDF1 expression in osteoblastic cells) (Nakao 2009)
	with PPBP may promote the formation of giant osteoclasts (Nakao 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in acute coronary syndromes (Smith 2006)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS