basic FUNCTION
| linking the integral membrane proteins to the underlying spectrin-actin cytoskeleton |
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playing key roles in activities such as cell |
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motility, activation, proliferation, contact and the maintenance of specialized membrane domains |
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participating in expression of multiple ion-channel /transporter proteins |
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required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate INSP3 receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes |
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playing a pivotal role in the function of the ITPR3 signaling microdomain |
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in heart, is critical for regulating membrane protein expression |
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having a role to stabilize the interaction between ATP1A1 and ITPR3 and is required for the stabilization of the signaling function of the ATP1A1/ITPR3 complex |
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adaptor required for sarcolemmal localization of dystrophin, as well as DCTN4 |
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is subject to alternative splicing that gives rise to unique polypeptides with diverse roles in cardiac function |
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role of ankyrin-B in normal cardiac electric activity |
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role of ANK2 in cardiac automaticity |
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role for in regulating KCNJ5 channel gating |
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may act as a membrane scaffolding protein to link KCNJ11 with the underlying actin- and spectrin-based cytoskeleton |
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regulates KCNJ11 membrane expression and function in heart |
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multifunctional adapter molecule implicated in membrane targeting of ion channels, transporters, and signaling molecules in excitable cells |
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CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function |
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ANK2 is required for PRX membrane anchoring and for maintenance of lens fiber cell hexagonal geometry, membrane skeleton organization, and biomechanics |