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FLASH GENE

Symbol

KNG1

contributors: mct/npt/shn - updated : 28-11-2017

HGNC name	kininogen 1
HGNC id	6383

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

KNG

Susceptibility

to shortening of the activated partial thromboplastin time (aPTT)

Variant & Polymorphism SNP	rs710446 increasing the risk of aPTT (Houlihan 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Kng1(-/-) mice are viable, but lacked plasma High-molecular-weight kininogen and low-molecular-weight kininogen , as well as DeltamHK-D5, displayed a significantly prolonged time to carotid artery occlusion following Rose Bengal administration and laser-induced arterial injury (