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FLASH GENE

Symbol

HOXD9

contributors: mct/npt - updated : 24-12-2009

HGNC name	homeobox D9
HGNC id	5140

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	2.44 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXD@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014213 2 - 1902 NP_055028 - 352 - Zappavigna (1991)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous optic nerve

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	expressed throughout the forelimb bud at early stages

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-4.4
	homolog to Drosophila abd-B

Homologene

FAMILY

Abd-B homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

genuine sequence-specific transcription factor (Zappavigna 1991)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with HOXD10 (cross-regulatory interactions between these genes might be essential for their proper expression) (Zappavigna 1991)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PSDY2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS