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FLASH GENE

Symbol

CRABP1

contributors: mct/npt - updated : 19-05-2010

HGNC name	cellular retinoic acid binding protein 1
HGNC id	2338

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.91 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	a consensus site, within an intron, 5 kb downstream from the promoter, which is implicated in regulation of retinoid signaling, and in PLZF-mediated repression

MAPPING

cloned

Y

linked

status

confirmed

Map	cen - (breakpoint in acute promyelocytic leukemia APL ) - CRABP1 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004378 4 - 782 NP_004369 - 137 - Flagiello (1997)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive mouth       moderately Endocrine neuroendocrine pituitary     moderately Lymphoid/Immune spleen       moderately Reproductive female system ovary     highly Skin/Tegument skin       lowly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective       lowly Epithelial barrier/lining     lowly

cells

System Cell Pubmed Species Stage Rna symbol   digestive Skin/Tegument keratinocyte

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

embryo, neonatal

Text	skin, embryonic tissue

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

a single eight-stranded continiously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site

HOMOLOGY

interspecies	homolog to rattus Crabp1 (99.27 pc)
	homolog to murine Crabp1 (99.27 pc)

Homologene

FAMILY	calycin superfamily
	fatty-acid binding protein (FABP) family

CATEGORY

signaling , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in retinoic acid-mediated differentiation and proliferation processes
	having a tumor-suppressor function in esophageal epithelium, and its epigenetic silencing may play a pivotal role during esophageal carcinogenesis

CELLULAR PROCESS	cell life, differentiation
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	transporter of small hydrophobic molecules

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

repressed by	during chondrogenesis
		T3 (repression of CRABP1 requires receptor interacting protein 140 (NRIP1) (Park 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         renal cell carcinoma tumoral     --low   hypermethylation associated with low expression in papillary thyroid carcinoma and in colorectal tumor development tumoral     --over   contributing to retinoid resistance, in RARA-ZBTB16 acute myeloid leukemia phenotype tumoral     --low   by methylation-associated silencing in esophageal squamous-cell carcinoma (Tanaka 2007)

Susceptibility

Variant & Polymorphism

Candidate gene	elevated level of CRABPI in the CSF of patients with Moyamoçya disease
Marker
Therapy target

ANIMAL & CELL MODELS