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FLASH GENE
Symbol ST6GAL1 contributors: mct/ - updated : 20-10-2007
HGNC name ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
HGNC id 10860
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic tail
  • a N-terminal signal anchor
  • stem region and a large catalytic luminal domain
    • HOMOLOGY
    Homologene
    FAMILY
  • sialyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • transferring sialic acid from the donor of substrate to galactose
  • generating HB-6, CDW75 and CD76 differentiation antigens
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text promoting B-lymphocyte activation
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of CD22 in B-lymphocytes
    • cell & other
    REGULATION
    Other secreted after cleavage by beta-site amyloid precursor protein-cleaving enzyme RACE
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral     --other  
    aberrant expression in breast cancer cells enhances their adhesion to brain endothelial cells and their passage through the blood-brain barrier
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS