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FLASH GENE

Symbol

ST6GAL1

contributors: mct/ - updated : 20-10-2007

HGNC name	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
HGNC id	10860

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_173216 8 - 4604 NP_775323 - 406 hepatic 2007 17697868 also called variant 1/isoform a long form NM_003032 7 - 4295 NP_003023 - 406 - 2007 17697868 also called variant 2/isoform a NM_173217 7 - 3947 NP_775324 - 175 - 2007 17697868 also called variant 3/isoform b short form

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine thyroid       highly Lymphoid/Immune lymph node       highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a short cytoplasmic tail
	a N-terminal signal anchor
	stem region and a large catalytic luminal domain

HOMOLOGY

Homologene

FAMILY

sialyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type II membrane protein

basic FUNCTION	transferring sialic acid from the donor of substrate to galactose
	generating HB-6, CDW75 and CD76 differentiation antigens

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	promoting B-lymphocyte activation

PATHWAY

metabolism

carbohydrate

signaling

glycosylation

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand of CD22 in B-lymphocytes

cell & other

REGULATION

Other

secreted after cleavage by beta-site amyloid precursor protein-cleaving enzyme RACE

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer tumoral     --other   aberrant expression in breast cancer cells enhances their adhesion to brain endothelial cells and their passage through the blood-brain barrier

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS