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FLASH GENE
Symbol ST6GAL1 contributors: mct/ - updated : 20-10-2007
HGNC name ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
HGNC id 10860
DNA
TYPE functioning gene
STRUCTURE 147.83 kb     8 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 4604 - 406 hepatic 2007 17697868
  • also called variant 1/isoform a
  • long form
    • 7 - 4295 - 406 - 2007 17697868
    also called variant 2/isoform a
    7 - 3947 - 175 - 2007 17697868
  • also called variant 3/isoform b
  • short form
    		•
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic tail
  • a N-terminal signal anchor
  • stem region and a large catalytic luminal domain
    • HOMOLOGY
    Homologene
    FAMILY
  • sialyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II membrane protein
    basic FUNCTION
  • transferring sialic acid from the donor of substrate to galactose
  • generating HB-6, CDW75 and CD76 differentiation antigens
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text promoting B-lymphocyte activation
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand of CD22 in B-lymphocytes
    • cell & other
    REGULATION
    Other secreted after cleavage by beta-site amyloid precursor protein-cleaving enzyme RACE
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral     --other  
    aberrant expression in breast cancer cells enhances their adhesion to brain endothelial cells and their passage through the blood-brain barrier
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS