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FLASH GENE
Symbol TRH contributors: mct - updated : 17-03-2014
HGNC name thyrotropin-releasing hormone
HGNC id 12298
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
precursor with six repetitive potential TRH coding sequences
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic,granule
intracellular,nucleus
basic FUNCTION
  • tripeptide hormone produced by the hypothalamus in response to hypothyroidism
  • may function as a melanoma autocrine growth factor
  • role of the TRH neuron as a central integrator of energy homeostasis
  • regulates energy homeostasis and autonomic responses
  • stimulates the release of prolactin as well as that of TSH
  • selectively stimulates human hair follicle pigmentation
  • inhibits melanin-concentrating hormone (MCH) neurons by increasing synaptic inhibition from local GABA neurons, and inhibition of MCH neurons may contribute to the TRH-mediated reduction in food intake and sleep
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
  • most proximal component of the hypothalamic-pituitary-thyroid axis that regulates thyroid hormone synthesis
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hypothalamic neuronal histamine mediates the TRH-induced suppression of feeding behavior
  • PPARG modulates hypothalamic TRH regulation
  • KLF4 plays a key role in the maturation of TRH expression in hypothalamic neurons
  • TRH is a highly specific regulator of TSHB, and TRH mediated induction of TSHB, at least in part by sequential stimulation of the NR4A1-TSHB genes through a PKC and ERK1/2 pathway
  • in the paraventricular nucleus (PVN) of the hypothalamus is regulated by thyroid hormone (TH)
  • CREB1 has been postulated to regulate TRH expression
  • TGFB2 regulates hypothalamic TRH expression through the TGFbeta inducible early gene-1 (TIEG1) during fetal development
    • cell & other
    REGULATION
    activated by by leptin (involves activation of STAT3 and this signaling pathway is important for regulation of the hypothalamic-pituitary-thyroid axis by leptin)
    Other
  • in the paraventricular nucleus (PVN) of the hypothalamus is regulated by thyroid hormone (TH)
    • ASSOCIATED DISORDERS
    corresponding disease(s) TRHD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by melanomas and dysplastic nevi
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS