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FLASH GENE

Symbol

TNFRSF1A

contributors: mct/pgu - updated : 07-06-2017

HGNC name	tumor necrosis factor receptor superfamily, member 1A
HGNC id	11916

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

TRAPS

related resource

INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       MVK (V377I) mutation and TNFRSF1A (R92Q) mutation with phenotype resembled a mixture of variant-type HIDS and TRAPS constitutional     --over   in fulminant hepatic failure cases in relation to acute viral hepatitis cases

Susceptibility

to myocardial infarction and carotid intima-media thickness to systemic lupus erythematosus to tuberculosis to hepatocellular carcinoma

Variant & Polymorphism other	R92Q increasing the risk of atherosclerosis
	T61I and R104Q, are associated with systemic lupus erythematosus
	polymorphisms increasing the risk of hepatocellular carcinoma

Candidate gene	could be a modifier gene in cystic fibrosis
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   interfering with the TNFRSF1A pathway offers the possibility to selectively block the formation of ectopic lymphoid tissue, opening a new perspective for the treatment of autoimmune and inflammatory diseases immunology inflammatory   potential therapeutic target in fulminant hepatic failure cases in relation to acute viral hepatitis cases

ANIMAL & CELL MODELS