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FLASH GENE
Symbol TSG22A contributors: mct - updated : 19-03-2008
DNA
TYPE functioning gene
MAPPING cloned   linked   status confirmed
Map cen - BCR - D22S219 ,CRYB@ - D22S1 - MN1 MN1 /TSG22B - (D22S41 , D22S46 , D22S33 ) - D22S56 - EWSR1 - NEFH - TSG22A (NF2 NF2 ) - LIF - D22S15 - D22S44 , D22S32 - D22S29 - D22S164 , MB - PDGFB - qter
Authors Wolff (92), Bijlsma (92)
Text see NF2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains schwannomin,cytoskeleton associated,moesin-ezrin-radixin like (merlin)
HOMOLOGY
Homologene
FAMILY ezrin/moesin/radixin-like (ERM) family
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • tumor suppressor gene(s)
  • responding and participating in reorganization of membrane-cytoplasmic interactions
  • likely operating by different pathways
  • ezrin/moesin/radixin-like (ERM) family member,responding and participating in reorganization of membrane-cytoplasmic interactions,likely operating by different pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other cytoskeleton associated
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in malignant mesothelioma, schwannoma, meningioma, breast and colorectal cancers
    tumoral   LOH    
    in malignant mesothelioma, sporadic, and in vestibular schwannoma, meningioma, colorectal
    tumoral   deletion    
    in glioma, meningioma, schwannoma
    tumoral   LOH    
    in prostate carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS