| protein
| binding TIMPs in a 1:1 stoechiometry |
|
interacting with PGF (PGF/MMP9 expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle) |
|
interacting with KLF5 (causes cartilage matrix degradation through transcriptional induction of MMP9, providing the first evidence that transcriptional regulation of a proteinase contributes to endochondral ossification and skeletal development) |
|
interacting with EGR1 (directly binds to the MMP9 promoter and plays an essential role for TNF1 induction of MMP9 transcription)  |
|
bind to several cell surface receptors including CD44, LRP1, LRP2 |
|
MMP9 expression induced by TGFA is a valid target of PPARD ligands in keratinocytes |
|
ITGB4 associates with MMP9 and its ectodomain is a target for cleavage by MMP9 |
|
PLG regulates MMP9-dependent CXCR4 expression to facilitate hematopoietic progenitor and stem cell (HPSC) mobilization in response to CSF3 |
|
CREB3 plays a critical role in MMP9 expression and is probably involved in invasion and metastasis of cervical cancer |
|
SMYD3 is an important new regulator of MMP9 transcription, providing a molecular link between SMYD3 overexpression and metastatic cancer progression |
|
MMP9 is a gene tightly regulated by the MXI1 gene |
|
induce the expression of MMP9 in macrophages, and MMP9 is known to be essential for tumor cell migration and invasion |
|
TNF promotes human RPE cell migration by inducing matrix metallopeptidase 9 (MMP-9) expression |
|
ADAM10 and/or MMP9 are playing important roles in constitutive and PACAP-induced RAGE shedding |
|
regulator of ERBB2 expression on human mammary epithelial cells |
|
PIWIL2 modulates the proliferation and metastasis of colon cancer via regulation of MMP9 transcriptional activity |
|
MMP9 cleaved NINJ1 in between Leu56 and Leu57 on its N-terminal ectodomain |
|
MMP9 constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of IAPP |
|
MTOR signaling is important to regulate the expression, activity and secretion of matrix metalloproteinases MMP9 |
|
ADAM17 mediates MMP9 expression in lung epithelial cells |
|
NUMBL could decrease the expression of TRAF6, CCND1, and MMP9 and increase the expression of CASP3 |
|
NFATC1 sequestering the SMAD3 prevents the proteasome mediated degradation of SKIL and SKIL has a role on the regulation of MMP2, MMP9 activity |
|
HDAC10 binds to the promoter regions of MMP2 and -9, deacetylates histones H3 and H4 in these regions, blocks the binding of RNA polymerase II, and consequently down-regulates MMP2 and -9 expression |
|
LCK upregulates FOXP3 by tyrosine phosphorylation, resulting in decreased MMP9, SKP2, and VEGFA expression, and suppressed cellular invasion |
|
MMP9 enhances PRKD2-mediated tumor angiogenesis by releasing extracellular matrix-bound VEGFA, increasing its bioavailability and angiogenesis |
|
MMP9 inhibits IL23A expression in dendritic cells by targeting membrane stem cell factor affecting lung IL17 response |
|
RAC1 controls surface mobilization of CD40LG on activated platelets and MMP9 secretion from neutrophils |
|
MMP9 was a downstream effector of HEY1 that promotes the invasion of osteosarcoma cells |
|
recruitment of MMP9 to the fibroblast cell surface occurs through its fibronectin-like (FN) domain and the molecule responsible for the recruitment is PLOD3 |
|
CTSK was responsible for the activation of pro-MMP9, with a key link between CTSK expression in tumors and bone and ECM remodeling, through MMP9 activation |
|
PGF may activate MMP9 via MAPK14 signaling pathway |
|
MMP9 is active in islets and cleaves IAPP |
|
CA8 might facilitate cancer cell invasion via the activation of PTK2-MMP9 signaling |
|
expression of MMP9 was enhanced with an upregulation of HOXC6 expression while HOXC6 downregulation lowered MMP9 gene expression levels |
|
INVS could upregulate the expression of CDH2, VIM, MMP2, and MMP9 |
|
overexpression of GADD45A activated MMP9 expression by inducing promoter demethylation |
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in cutaneous squamous cell carcinoma with metastatic potential and in in sporadic colorectal cancer | | tumoral
|
|
| --low
|
| |
in diffuse type gastric carcinoma, and in hereditary non-polyposis colorectal carcinoma | | tumoral
|
|
| --over
|
| |
in breast cancer and in prostate cancer with aggressive phenotype | | constitutional
|
|
|
| gain of function
| |
in chronic obstructive pulmonary disease | | constitutional
|
|
| --over
|
| |
at the site of abdominal aortic aneurysm rupture | | constitutional
|
|
| --over
|
| |
in arthritis, degrading non-collagen matrix components of the joints | | constitutional
|
|
| --over
|
| |
higher in MADYS1 (mandibuloacral dysplasia type A) sera compared with healthy controls | | constitutional
|
|
| --over
|
| |
in skeletal muscle tissues after nerve injury, heart failure and inflammatory myopathy, and exacerbate dystrophinopathy by augmenting fiber necrosis, ECM degradation, inflammation and fibrosis | | tumoral
|
|
| --over
|
| |
is associated with accumulation of the pleural effusion in malignancy | | constitutional
|
|
| --over
|
| |
hypertension-induced atherosclerosis was associated with significantly increased levels of MMP9 mRNA, which may enhance both the deposition of types I and III collagen and atherosclerotic plaque formation | | constitutional
|
|
| --over
|
| |
may be linked with the intractable epilepsy caused by focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) | | constitutional
|
|
|
| gain of function
| |
SPARC, MMP2 and MM9 were significantly up-regulated in intracranial aneurysms relative to the expression levels in the normal Circle of Willis arteries | | constitutional
|
|
| --low
|
| |
AHSG, MMP9, and MMP3 levels were significantly lower in migraine than controls | | tumoral
|
|
| --over
|
| |
in the invasive group of pituitary adenomas (pMID: 21279695) | |
