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FLASH GENE
Symbol ACY1 contributors: - updated : 13-10-2006
HGNC name aminoacylase 1
HGNC id 177
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a dimerization domain flanked by two peptidase domains, essential for catalytic activity
conjugated PhosphoP
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to rattus Acy1
ortholog to murine Acy1
Homologene
FAMILY peptidase M20B family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • acting as a metallopeptidase
  • catalyzing the hydrolysis of acylated L-amino acids (except L-aspartate) to L-amino acids and acyl group
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACY1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS