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FLASH GENE
Symbol ACY1 contributors: - updated : 13-10-2006
HGNC name aminoacylase 1
HGNC id 177
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D3S11 - PDHB PDHB - MST1 - RHOA - GNAI2 - ACY1 - D3S92 - D3S2 - PTPRG - D3S6 - cen
Authors LaForgia (93), Shridhar (94)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver   highly
Lymphoid/Immunespleen   moderately
 thymus   moderately
Reproductivefemale systemuteruscervix predominantly
 female systemovary  moderately
Skin/Tegumentskin   moderately
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a dimerization domain flanked by two peptidase domains, essential for catalytic activity
conjugated PhosphoP
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to rattus Acy1
ortholog to murine Acy1
Homologene
FAMILY peptidase M20B family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • acting as a metallopeptidase
  • catalyzing the hydrolysis of acylated L-amino acids (except L-aspartate) to L-amino acids and acyl group
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACY1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS