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FLASH GENE

Symbol

CD80

contributors: mct - updated : 13-02-2015

HGNC name	CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
HGNC id	1700

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	35.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node           tonsils         Reproductive female system breast mammary gland     Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune B cell Lymphoid/Immune dendritic cell Lymphoid/Immune lymphocyte Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	Ig variable-like (IgV) domains, Ig constant-like (IgC) domains and intracellular domains
	a transmembrane domain (1TM)
	a cytoplasmic domain, component of a costimulatory signal with B7-2 (CD86) and CD28

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Cd80

Homologene

FAMILY

Ig superfamily, k1 B box family, B7 family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	membrane protein type 1

basic FUNCTION	involved in the costimulatory signal essential for t lymphocytes activation
	T cell proliferation and cytokine production
	playing a role in stimulating T lymphocyte activation
	direct signaling through CD86/CD80 is a potent regulator of IgG secretion by previously activated B cells
	CD80/CD86 engagement results in DC production of the pro-inflammatory cytokine IL6, which is necessary for full T cell activation
	distinct but complementary roles of CD80 and CD86 IgV and IgC domains in T cell activation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CD28, CD86 ligand
	SPI1 is a critical factor for the expression of CD80 and CD86
	interaction of CD86, CD80 with appropriate receptors is essential for an effective T cell response

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   inadequate expression during early oral squamous carcinoma formation may contribute to the escape of tumors from immune elimination

Susceptibility

putative susceptibility gene for rheumatoid arthritis Systemic lupus erythematosus (SLE)

Variant & Polymorphism other	genetic variants increasing the risk of Systemic lupus erythematosus (SLE)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS