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FLASH GENE

Symbol

ALPPL2

contributors: - updated : 22-11-2005

HGNC name	alkaline phosphatase, placental-like 2
HGNC id	441

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage
cell lines	germ cells tumor lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one active site,
	two zinc Zn2+ molecules, and magnesium Mg2+ as a cofactor

conjugated

MetalloP

mono polymer

homomer , dimer

HOMOLOGY

intraspecies

paralog to ACPP,ALPL

Homologene

FAMILY

alkaline phosphatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	attached to the membrane by a gpi-anchor

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complex of identical subunits

INTERACTION

DNA

RNA

small molecule	metal binding,
	zinc Zn2+ binding
	magnesium Mg2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in seminoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS