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FLASH GENE
Symbol HOXD8 contributors: mct/npt - updated : 24-12-2009
HGNC name homeobox D8
HGNC id 5139
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-4.3
    homolog to Drosophila antp,Ubx,abd-A
    Homologene
    FAMILY
  • Antp homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in adult genitourinary tract function and in limb development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PROX1 (transcriptional networks of PROX1 and HOXD8 play important roles in the maturation and maintenance of lymphatic vessels) (Harada 2009)
    • cell & other
    REGULATION
    induced by PROX1 in murine embryonic-stem-cell-derived endothelial cells, a finding confirmed in human umbilical vein endothelial cells (HUVECs) and human dermal LECs (HDLECs) (Harada 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Hoxd3 and Hoxd8 will be differentially expressed in mid- and late-gestational wounds compared with normal skin (Jain 2008)