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FLASH GENE

Symbol

HOXD8

contributors: mct/npt - updated : 24-12-2009

HGNC name	homeobox D8
HGNC id	5139

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q31.1      Physical location : 176.994.476 - 176.996.726
Synonym name	homeo box D8 (4E)
	Hox-4.5, mouse, homolog of
	homeobox D8
Synonym symbol(s)	HOX4E, HOX4, HXD8, HOX5.4

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	2.25 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map

see HOXD@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_019558 2 - 1879 NP_062458 - 290 - Limongi (2000)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain           ganglia sensory ganglia dorsal root     Reproductive female system breast       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory       Muscular striatum skeletal     Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-4.3
	homolog to Drosophila antp,Ubx,abd-A

Homologene

FAMILY

Antp homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

may be playing a role in adult genitourinary tract function and in limb development

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with PROX1 (transcriptional networks of PROX1 and HOXD8 play important roles in the maturation and maintenance of lymphatic vessels) (Harada 2009)

cell & other

REGULATION

induced by

PROX1 in murine embryonic-stem-cell-derived endothelial cells, a finding confirmed in human umbilical vein endothelial cells (HUVECs) and human dermal LECs (HDLECs) (Harada 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Hoxd3 and Hoxd8 will be differentially expressed in mid- and late-gestational wounds compared with normal skin (Jain 2008)