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FLASH GENE
Symbol HOXD3 contributors: mct/npt - updated : 22-12-2009
HGNC name homeo box D3
HGNC id 5137
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-4.1
    homolog to Drosophila Zen
    Homologene
    FAMILY
  • ANTP homeobox family
    • CATEGORY adhesion , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in the regulation of cell adhesion processes
  • potent proangiogenic transcription factor that promotes angiogenesis by modulating the expression of matrix-degrading proteinases, integrins, and extracellular matrix components (Chen 2004)
  • may play an important role in regulating cerebral angiogenesis (Chen 2004)
  • may be playing a role in scarless wound repair (Jain 2008)
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis (Chen 2004)
    ANIMAL & CELL MODELS
    Hoxd3 and Hoxd8 will be differentially expressed in mid- and late-gestational wounds compared with normal skin (Jain 2008)