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FLASH GENE

Symbol

HOXD3

contributors: mct/npt - updated : 22-12-2009

HGNC name	homeo box D3
HGNC id	5137

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	9.02 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXD@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006898 3 - 2319 NP_008829 - 432 - Chen (2004)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary         female system breast

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-4.1
	homolog to Drosophila Zen

Homologene

FAMILY

ANTP homeobox family

CATEGORY

adhesion , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be playing a role in the regulation of cell adhesion processes
	potent proangiogenic transcription factor that promotes angiogenesis by modulating the expression of matrix-degrading proteinases, integrins, and extracellular matrix components (Chen 2004)
	may play an important role in regulating cerebral angiogenesis (Chen 2004)
	may be playing a role in scarless wound repair (Jain 2008)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis (Chen 2004)

ANIMAL & CELL MODELS

Hoxd3 and Hoxd8 will be differentially expressed in mid- and late-gestational wounds compared with normal skin (Jain 2008)