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FLASH GENE
Symbol UCP1 contributors: mct - updated : 28-03-2018
HGNC name uncoupling protein 1 (mitochondrial, proton carrier)
HGNC id 12517
ASSOCIATED DISORDERS
corresponding disease(s)
related resource MITOP database
Susceptibility obesity, diabetes
Variant & Polymorphism SNP
  • a minor role of the 5'utr polymorphism in obesity and diabetes
  • SNP in type 2 diabetes mellitus (allele GG)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • transgenic mice with muscular overexpression of uncoupling protein 1 (Ucp1), a potent mitochondrial uncoupler, displayed age-dependent deterioration of the NMJ that correlated with progressive signs of denervation and a mild late-onset motor neuron pathology