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FLASH GENE
Symbol GP9 contributors: npt/mct - updated : 24-02-2010
HGNC name glycoprotein IX (platelet)
HGNC id 4444
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal signal peptide
  • one extracellular leucine-rich domain (LRD)
  • ectodomains of both GP1BB and GP9subunits contain two leucine-rich repeats (LRR) and share high sequence similarity (Mo 2009)
  • a hydrophobic transmembrane domain near the C terminus
    • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Gp9
    Homologene
    FAMILY
  • leucine-rich glycoprotein family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane, type I membrane protein
    basic FUNCTION
  • GP1b complex involved in adhesion of a damaged vessel wall to the extra cellular matrix
  • functioning as a receptor for von Willebrand factor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the von Willebrand receptor where it is non covalently bound to the GP1B complex (heterodimer composed of disulfide linked GP-Ib alpha and beta)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target gene for FLI1
  • interacting with GP1BB (putative convex surface of the LRR domain in GP9 is sufficient, in the context of full-length subunit, to mediate its association with GP1BB) (Mo 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GP1BC
    related resource Bernard-Soulier Syndrome database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS