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FLASH GENE
Symbol GP9 contributors: npt/mct - updated : 24-02-2010
HGNC name glycoprotein IX (platelet)
HGNC id 4444
Corresponding disease
GP1BC giant platelet syndrome 1C
Location 3q21.3      Physical location : 128.779.644 - 128.781.253
Synonym name CD42a antigen
Synonym symbol(s) CD42a, GPIX
DNA
TYPE functioning gene
STRUCTURE 1.61 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 858 - 177 - Luo (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Respiratorylung   lowly
Visualeye   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal signal peptide
  • one extracellular leucine-rich domain (LRD)
  • ectodomains of both GP1BB and GP9subunits contain two leucine-rich repeats (LRR) and share high sequence similarity (Mo 2009)
  • a hydrophobic transmembrane domain near the C terminus
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Gp9
    Homologene
    FAMILY
  • leucine-rich glycoprotein family
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to plasma membrane, type I membrane protein
    basic FUNCTION
  • GP1b complex involved in adhesion of a damaged vessel wall to the extra cellular matrix
  • functioning as a receptor for von Willebrand factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • component of the von Willebrand receptor where it is non covalently bound to the GP1B complex (heterodimer composed of disulfide linked GP-Ib alpha and beta)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target gene for FLI1
  • interacting with GP1BB (putative convex surface of the LRR domain in GP9 is sufficient, in the context of full-length subunit, to mediate its association with GP1BB) (Mo 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GP1BC
    related resource Bernard-Soulier Syndrome database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS