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FLASH GENE
Symbol MAST3 contributors: mct - updated : 05-06-2024
HGNC name microtubule associated serine/threonine kinase 3
HGNC id 19036
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
text abundant expression of MAST3 in antigen-presenting cells
basic FUNCTION
  • is a modulator of the inflammatory response through regulation of immune gene expression in the gut of IBD patients
  • modulates the activity of inflammation-related transcription factor nuclear factor kappa B
  • play a critical role in regulating the immune response of IBD and involved in the process of cytoskeleton organization, intracellular signal transduction and peptidyl-serine phosphorylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARRP19 is phosphorylated by MAST3, an enzyme of previously unknown function that is enriched in striatum
  • ARPP9 is a striatal-enriched inhibitor of protein phosphatase 2A regulated by MAST3
  • MAST3 might promote the proliferation and inflammation of fibroblast-like synovial cells (FLSs) by regulating NFKB1 signaling pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEE108
    Susceptibility
  • to Inflammatory bowel disease (IBD)
    • Variant & Polymorphism other
  • four MAST3 coding variants, including a non-synonymous SNP rs8108738, correlated to rs273506 and associated with IBD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS