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FLASH GENE

Symbol

MAST3

contributors: mct - updated : 05-06-2024

HGNC name	microtubule associated serine/threonine kinase 3
HGNC id	19036

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain basal nuclei striatum   highly Homo sapiens   brain forebrain cerebral cortex     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	abundant expression of MAST3 in antigen-presenting cells

basic FUNCTION	is a modulator of the inflammatory response through regulation of immune gene expression in the gut of IBD patients
	modulates the activity of inflammation-related transcription factor nuclear factor kappa B
	play a critical role in regulating the immune response of IBD and involved in the process of cytoskeleton organization, intracellular signal transduction and peptidyl-serine phosphorylation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ARRP19 is phosphorylated by MAST3, an enzyme of previously unknown function that is enriched in striatum
	ARPP9 is a striatal-enriched inhibitor of protein phosphatase 2A regulated by MAST3
	MAST3 might promote the proliferation and inflammation of fibroblast-like synovial cells (FLSs) by regulating NFKB1 signaling pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEE108

Susceptibility

to Inflammatory bowel disease (IBD)

Variant & Polymorphism other

four MAST3 coding variants, including a non-synonymous SNP rs8108738, correlated to rs273506 and associated with IBD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS