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FLASH GENE
Symbol SLC20A1 contributors: mct/pgu - updated : 27-04-2011
HGNC name solute carrier family 20 (phosphate transporter), member 1
HGNC id 10946
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
multiple potential transmembrane domains
HOMOLOGY
interspecies homolog to murine Slc20a1
homolog to Drosophila CG7628
homolog to C.elegans C48A7.2
Homologene
FAMILY
CATEGORY receptor membrane , transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • putatively involved in the regulation of Pi handling in bone forming cells
  • sodium-dependent phosphate symporter
  • critical gene for normal developmental liver growth (
  • involved in phosphate uptake (essential role for smooth muscle cells calcification and phenotypic modulation in response to elevated phosphate)
  • is involved in cell proliferation, tumor growth and cell signaling independently of its transport function
  • functions as a sodium-Pi (inorganic phosphate) symporter
  • could play a role during cancer pathogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text small molecule transport
    PATHWAY
    metabolism other
    signaling
    phosphate
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRB is involved in angiogenesis and in the regulation of inorganic phosphate (Pi) transport in vascular smooth muscle cells via SLC20A1
  • NELL1 increases pre-osteoblast mineralization using both phosphate transporter SLC20A1, SLC20A2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS