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FLASH GENE
Symbol SLC20A1 contributors: mct/pgu - updated : 27-04-2011
HGNC name solute carrier family 20 (phosphate transporter), member 1
HGNC id 10946
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivesalivary gland   highly
Endocrinethyroid   highly
Nervousbrain    
Reproductivefemale systemuterus  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
multiple potential transmembrane domains
HOMOLOGY
interspecies homolog to murine Slc20a1
homolog to Drosophila CG7628
homolog to C.elegans C48A7.2
Homologene
FAMILY
CATEGORY receptor membrane , transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • putatively involved in the regulation of Pi handling in bone forming cells
  • sodium-dependent phosphate symporter
  • critical gene for normal developmental liver growth (
  • involved in phosphate uptake (essential role for smooth muscle cells calcification and phenotypic modulation in response to elevated phosphate)
  • is involved in cell proliferation, tumor growth and cell signaling independently of its transport function
  • functions as a sodium-Pi (inorganic phosphate) symporter
  • could play a role during cancer pathogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text small molecule transport
    PATHWAY
    metabolism other
    signaling
    phosphate
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRB is involved in angiogenesis and in the regulation of inorganic phosphate (Pi) transport in vascular smooth muscle cells via SLC20A1
  • NELL1 increases pre-osteoblast mineralization using both phosphate transporter SLC20A1, SLC20A2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS