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FLASH GENE

Symbol

SLC20A1

contributors: mct/pgu - updated : 27-04-2011

HGNC name	solute carrier family 20 (phosphate transporter), member 1
HGNC id	10946

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.88 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	cen - D2S2016 - D2S340 - D2S1893 - D2S2087 - D2S1888 - D2S1896 - SLC20A1 - IL1A - IL1B - IL1RN - D2S43 /PAX8 - D2S178 - D2S121 - D2S308 - qter
Authors	SCW2-4 (96)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005415 11 - 3297 NP_005406 - 679 - 2007 17494632

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive salivary gland       highly Endocrine thyroid       highly Nervous brain         Reproductive female system uterus     highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Connective bone       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

multiple potential transmembrane domains

HOMOLOGY

interspecies	homolog to murine Slc20a1
	homolog to Drosophila CG7628
	homolog to C.elegans C48A7.2

Homologene

FAMILY

CATEGORY

receptor membrane , transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	putatively involved in the regulation of Pi handling in bone forming cells
	sodium-dependent phosphate symporter
	critical gene for normal developmental liver growth (
	involved in phosphate uptake (essential role for smooth muscle cells calcification and phenotypic modulation in response to elevated phosphate)
	is involved in cell proliferation, tumor growth and cell signaling independently of its transport function
	functions as a sodium-Pi (inorganic phosphate) symporter
	could play a role during cancer pathogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

text	small molecule transport

PATHWAY

metabolism

other

signaling

phosphate

a component

INTERACTION

DNA

RNA

small molecule

protein	PDGFRB is involved in angiogenesis and in the regulation of inorganic phosphate (Pi) transport in vascular smooth muscle cells via SLC20A1
	NELL1 increases pre-osteoblast mineralization using both phosphate transporter SLC20A1, SLC20A2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS