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FLASH GENE
Symbol TMEM132C contributors: mct - updated : 22-03-2022
HGNC name transmembrane protein 132C
HGNC id 25436
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extra-cellular portions contain five conserved domains including three tandem immunoglobulin domains, and a cohesin domain homologue
    • HOMOLOGY
    Homologene
    FAMILY TMEM132 family of proteins
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • potential cellular adhesion function for TMEM132 family, connecting the extracellular medium with the intracellular actin cytoskeleton
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in hyperglycemia and correlated negatively with insulin secretion, suggesting a potential pathogenic role in diabetes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential diagnostic and prognostic markers in triple-negative breast cancer
    • Therapy target
    ANIMAL & CELL MODELS