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FLASH GENE

Symbol

OTUD5

contributors: mct - updated : 08-12-2021

HGNC name	OTU deubiquitinase 5
HGNC id	25402

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	localizes to DNA double strand breaks (DSBs)

basic FUNCTION	localizes to DNA double strand breaks (DSBs), interacts with UBR5 and represses the RNA Pol II elongation and RNA synthesis
	OTUD5 is a new regulator of the DNA damage response
	OTUD5 is indispensable for STING1-mediated antiviral and antitumor immunity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	as a novel deubiquitinating enzyme for TP53, OTUD5 is required for the stabilization and the activation of a TP53 response
	essential role for the PDCD5-OTUD5 network in TP53 activation
	OTUD5 is a specific stabilizer of the UBR5 E3 ligase
	OTUD5 regulates gene transcription and suppresses tumorigenesis by deubiquitinating TRIM25
	OTUD5 interacts with STING1, cleaves its K48-linked polyubiquitin chains, and promotes its stability
	is a novel positive regulator of the MTOR and CRTC2 signaling pathways (PMISD: 33110214)

cell & other

REGULATION

Phosphorylated by

MTOR that directly phosphorylated OTUD5 and activated its DUB activity

Other

likely positive feedback loop between OTUD5 and MTOR signaling pathway

ASSOCIATED DISORDERS

corresponding disease(s)

MCAND

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in tumor tissues

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS