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FLASH GENE
Symbol METTL21C contributors: mct - updated : 13-01-2021
HGNC name methyltransferase like 21C
HGNC id 33717
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY METTL21 family of proteins
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • with METTL21A, EEF1AKMT3, METTL21C methylates chaperones involved in the etiology of both myopathy and inclusion body myositis with Paget's disease
  • is a skeletal muscle-specific lysine methyltransferase
  • METTL21C is an important modulator of protein degradation in skeletal muscle under both normal and enhanced protein breakdown conditions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • might exert its bone-muscle pleiotropic function via the regulation of the NFKB1 signaling pathway, which is critical for bone and muscle homeostasis
  • METTL21C trimethylates VCP on the Lys315 residue and loss of this modification reduced VCP hexamer formation and ATPase activity
  • HSPA8 is a METTL21C substrate suggesting that nonhistone methylation has a physiological function in protein stabilization
  • role for the METTL21C-AARS1 axis in the regulation of protein synthesis in muscle tissue
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS