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FLASH GENE

Symbol

L1TD1

contributors: mct - updated : 25-05-2020

HGNC name	LINE1 type transposase domain containing 1
HGNC id	25595

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

SUBCELLULAR LOCALIZATION

basic FUNCTION	dispensability of L1TD1 in pluripotency, despite its specific expression
	play an important role in pluripotency maintenance
	L1TD1 has likely been recurrently selected for functional novelty, perhaps for a role in genome defense
	SPAG6 and L1TD1 are tumor-specifically methylated in non-small cell lung cancer (NSCLC) and DNA methylation is involved in the transcriptional regulation of these genes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

NANOG can activate the L1TD1 upstream promoter region, and L1TD1 is a downstream target of NANOG

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in non-small cell lung cancer (NSCLC) tumoral     --over   occurs in medulloblastoma cells, reaching levels similar to those found in ESCs, and is correlated with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	increased expression of L1TD1 as a prognostic marker predicting longer disease-free survival in colon cancer patients
Therapy target
	System Type Disorder Pubmed cancer brain   L1TD1 as a potential therapeutic target in malignant brain tumors

ANIMAL & CELL MODELS