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FLASH GENE
Symbol SPACA5 contributors: mct - updated : 24-03-2020
HGNC name sperm acrosome associated 5
HGNC id 31353
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide of 18 amino acids
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may have a role in sperm function, innate immunity and other physiological process as well
  • may be important in male spermatogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopically expressed in the cytoplasm of bladder transitional cell carcinoma (TCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • attractive candidate antigen for cancer testis
    • Marker
  • biomarker for male fertility
    • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    may be used as a potential target for specific immunotherapy in patients suffering from bladder TCC
    ANIMAL & CELL MODELS