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FLASH GENE

Symbol

SPACA5

contributors: mct - updated : 24-03-2020

HGNC name	sperm acrosome associated 5
HGNC id	31353

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.40 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_205856 5 - 732 NP_995328 - 159 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatid Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a signal peptide of 18 amino acids

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may have a role in sperm function, innate immunity and other physiological process as well
	may be important in male spermatogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   ectopically expressed in the cytoplasm of bladder transitional cell carcinoma (TCC)

Susceptibility

Variant & Polymorphism

Candidate gene	attractive candidate antigen for cancer testis
Marker	biomarker for male fertility
Therapy target
	System Type Disorder Pubmed cancer urinary   may be used as a potential target for specific immunotherapy in patients suffering from bladder TCC

ANIMAL & CELL MODELS