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FLASH GENE
Symbol SPACA5 contributors: mct - updated : 24-03-2020
HGNC name sperm acrosome associated 5
HGNC id 31353
Location Xp11.23      Physical location : 47.863.733 - 47.991.995
Synonym name
  • lysozyme-like protein 5
  • sperm lysozyme-like protein 2
  • sperm-specific lysozyme-like protein X
  • testicular tissue protein Li 113
    • Synonym symbol(s) LYC5, LYZL5, PNPK6288, SLLP-X, SLLP2, UNQ6288
    EC.number 3.2.1.17
    DNA
    TYPE functioning gene
    STRUCTURE 5.40 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 732 - 159 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide of 18 amino acids
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may have a role in sperm function, innate immunity and other physiological process as well
  • may be important in male spermatogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPACA3, LYZL4 and SPACA5 possess hyaluronan binding ability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopically expressed in the cytoplasm of bladder transitional cell carcinoma (TCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • attractive candidate antigen for cancer testis
    • Marker
  • biomarker for male fertility
    • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    may be used as a potential target for specific immunotherapy in patients suffering from bladder TCC
    ANIMAL & CELL MODELS