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FLASH GENE
Symbol NKAP contributors: mct - updated : 21-11-2019
HGNC name NFKB activating protein [Homo sapiens
HGNC id 29873
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text
  • nuclear speckle protein
    • basic FUNCTION
  • NKAP functions as a transcriptional repressor, acting on NOTCH1 target genes, and is required for alphabeta T cell development
  • NKAP is one of a very small number of transcriptional regulators that is absolutely required for adult hematopoietic stem cells (HSCs) maintenance and survival
  • NKAP is required for T cell maturation and the acquisition of functional competency
  • NKAP and HDAC3 functionally interact to control invariant natural killer T cell development
  • potential additional role of NKAP outside of subventricular zone (SVZ) progenitor cells
  • NKAP is a novel and key regulator of mitosis, and its dysregulation might contribute to tumorigenesis by causing chromosomal instability
  • NKAP is required for conventional T cell maturation as it prevents complement-mediated attack in the periphery
  • NKAP functions in different complexes in different cell types
  • involved in transcriptional repression, immune cell development, maturation, acquisition of functional competency and maintenance of hematopoiesis
  • NKAP promoted the proliferation, migration and invasion of Ewing sarcoma (ES) cells, at least partly, through the AKT signaling pathway
  • nucleoplasmic protein that is currently known as a transcriptional regulatory molecule via its interaction with HDAC3 and spliceosomal proteins
  • essential roles of NKAP in neural development as well as in bone and connective tissue
  • critical role of NKAP in transcriptional regulation
  • multi-functional nuclear protein that has been shown to be essential for hematopoiesis
  • may limit cellular stress that can trigger cell cycle withdrawal or cell death, a role critical for the maintenance of a viable pool of hematopoietic progenitors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is a part of the spliceosomal complex, but the dysfunction of NKAP may not cause increased aberrant or alternative splicing
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NKAP is critical for chromosome alignment through anchoring CENPE to kinetochores
  • interaction between NKAP and HDAC3 is critical for T Cell maturation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DDMHH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gliomas could promote tumor growth by contributing to a NOTCH1-dependent immune-suppressive tumor microenvironment
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nkap mutant zebrafish with a C-terminally truncated Nkap demonstrate severe developmental defects