Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NKAP contributors: mct - updated : 21-11-2019
HGNC name NFKB activating protein [Homo sapiens
HGNC id 29873
DNA
TYPE functioning gene
STRUCTURE 23.08 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 5942 - 415 - 2016 27694884
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonthalamus   Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
Olfactory (smell)olfactory bulb     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text
  • nuclear speckle protein
    • basic FUNCTION
  • NKAP functions as a transcriptional repressor, acting on NOTCH1 target genes, and is required for alphabeta T cell development
  • NKAP is one of a very small number of transcriptional regulators that is absolutely required for adult hematopoietic stem cells (HSCs) maintenance and survival
  • NKAP is required for T cell maturation and the acquisition of functional competency
  • NKAP and HDAC3 functionally interact to control invariant natural killer T cell development
  • potential additional role of NKAP outside of subventricular zone (SVZ) progenitor cells
  • NKAP is a novel and key regulator of mitosis, and its dysregulation might contribute to tumorigenesis by causing chromosomal instability
  • NKAP is required for conventional T cell maturation as it prevents complement-mediated attack in the periphery
  • NKAP functions in different complexes in different cell types
  • involved in transcriptional repression, immune cell development, maturation, acquisition of functional competency and maintenance of hematopoiesis
  • NKAP promoted the proliferation, migration and invasion of Ewing sarcoma (ES) cells, at least partly, through the AKT signaling pathway
  • nucleoplasmic protein that is currently known as a transcriptional regulatory molecule via its interaction with HDAC3 and spliceosomal proteins
  • essential roles of NKAP in neural development as well as in bone and connective tissue
  • critical role of NKAP in transcriptional regulation
  • multi-functional nuclear protein that has been shown to be essential for hematopoiesis
  • may limit cellular stress that can trigger cell cycle withdrawal or cell death, a role critical for the maintenance of a viable pool of hematopoietic progenitors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is a part of the spliceosomal complex, but the dysfunction of NKAP may not cause increased aberrant or alternative splicing
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NKAP is critical for chromosome alignment through anchoring CENPE to kinetochores
  • interaction between NKAP and HDAC3 is critical for T Cell maturation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DDMHH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gliomas could promote tumor growth by contributing to a NOTCH1-dependent immune-suppressive tumor microenvironment
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nkap mutant zebrafish with a C-terminally truncated Nkap demonstrate severe developmental defects