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FLASH GENE
Symbol YTHDF3 contributors: mct - updated : 06-11-2019
HGNC name YTH N6-methyladenosine RNA binding protein 3
HGNC id 26465
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY YTH (YT521-B homology) domain family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of m6A-modified mRNAs in the cytoplasm
  • new role for YTHDF3 in shaping the selectivity of stress response
  • role of YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of FOXO3 mRNA under homeostatic conditions
  • enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), regulates the pace of the circadian clock
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YTHDF3 cooperates with two cofactors, PABP1 and EIF4G2, to promote FOXO3 translation by binding to the translation initiation region of FOXO3 mRNA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of YTHDF1, YTHDF3 and KIAA1429 predicted poor prognosis in terms of overall survival (OS) in breast cancer (BRC)
    tumoral       loss of function
    METTL14, YTHDF3 and ALKBH5 were downregulated in Colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • upregulation of YTHDF3 was an independent prognostic factor for overall survival (OS) in patients with breast cancer (BRC)
    • Therapy target
    ANIMAL & CELL MODELS