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FLASH GENE

Symbol

YTHDF3

contributors: mct - updated : 06-11-2019

HGNC name	YTH N6-methyladenosine RNA binding protein 3
HGNC id	26465

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001277813 6 - 5317 NP_001264742 - 588 - 2017 28106076 NM_001277815 6 - 5202 NP_001264744 - 534 - 2017 28106076 NM_001277816 4 - 5085 NP_001264745 - 534 - 2017 28106076 NM_152758 5 - 5095 NP_689971 - 585 - 2017 28106076 NM_001277817 5 - 5010 NP_001264746 - 534 - 2017 28106076 NM_001277818 5 - 4931 NP_001264747 - 534 - 2017 28106076 NM_001277814 6 - 5071 NP_001264743 - 588 - 2017 28106076

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

YTH (YT521-B homology) domain family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of m6A-modified mRNAs in the cytoplasm
	new role for YTHDF3 in shaping the selectivity of stress response
	role of YTHDF3 as a negative regulator of antiviral immunity through the translational promotion of FOXO3 mRNA under homeostatic conditions
	enzymes important for N6-methyladenosine RNA transmethylation (METTL4, YWHAB, and YTHDF3), regulates the pace of the circadian clock

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

YTHDF3 cooperates with two cofactors, PABP1 and EIF4G2, to promote FOXO3 translation by binding to the translation initiation region of FOXO3 mRNA

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   of YTHDF1, YTHDF3 and KIAA1429 predicted poor prognosis in terms of overall survival (OS) in breast cancer (BRC) tumoral       loss of function METTL14, YTHDF3 and ALKBH5 were downregulated in Colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	upregulation of YTHDF3 was an independent prognostic factor for overall survival (OS) in patients with breast cancer (BRC)
Therapy target

ANIMAL & CELL MODELS