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FLASH GENE
Symbol LY6K contributors: mct - updated : 27-03-2019
HGNC name lymphocyte antigen 6 family member K
HGNC id 24225
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • LY6K is a newly identified factor involved in sperm fertilizing ability
  • overexpression of LY6K suppresses T cell development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TEX101 is physically associated with LY6K within the testis, and TEX101 collaborates likely with LY6K on the cell membrane and may play a role in spermatogenesis
  • TEX101 is associated with LY6K during spermatogenesis in testis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer patients with distant metastases than those without distant metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • a cancer-testis antigen, LY6K, should be useful as a new type of tumor biomarker
    • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    LY6K is a potential therapeutic target for cancer
    ANIMAL & CELL MODELS