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FLASH GENE
Symbol LY6K contributors: mct - updated : 27-03-2019
HGNC name lymphocyte antigen 6 family member K
HGNC id 24225
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • LY6K is a newly identified factor involved in sperm fertilizing ability
  • overexpression of LY6K suppresses T cell development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TEX101 is physically associated with LY6K within the testis, and TEX101 collaborates likely with LY6K on the cell membrane and may play a role in spermatogenesis
  • TEX101 is associated with LY6K during spermatogenesis in testis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer patients with distant metastases than those without distant metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • a cancer-testis antigen, LY6K, should be useful as a new type of tumor biomarker
    • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    LY6K is a potential therapeutic target for cancer
    ANIMAL & CELL MODELS