Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

LY6K

contributors: mct - updated : 27-03-2019

HGNC name	lymphocyte antigen 6 family member K
HGNC id	24225

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.09 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001160354 3 - 1994 NP_001153826 - 120 - 2012 22988241 NM_017527 3 - 1747 NP_059997 17 165 . GPI-anchored form 2012 22988241 NM_001160355 3 - 1715 NP_001153827 12 105 - 2012 22988241 water-soluble (non-membrane) form

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	LY6K is a newly identified factor involved in sperm fertilizing ability
	overexpression of LY6K suppresses T cell development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	TEX101 is physically associated with LY6K within the testis, and TEX101 collaborates likely with LY6K on the cell membrane and may play a role in spermatogenesis
	TEX101 is associated with LY6K during spermatogenesis in testis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer patients with distant metastases than those without distant metastases

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	a cancer-testis antigen, LY6K, should be useful as a new type of tumor biomarker
Therapy target
	System Type Disorder Pubmed cancer     LY6K is a potential therapeutic target for cancer

ANIMAL & CELL MODELS