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FLASH GENE
Symbol LRRC56 contributors: mct - updated : 27-11-2018
HGNC name leucine rich repeat containing 56
HGNC id 25430
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five leucine-rich repeat domains conserved across species whose motile cilia are assembled by intraflagellar transport (IFT)
    • HOMOLOGY
    interspecies homolog to Chlamydomonas Oda8
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • is recruited to the cilium during axoneme construction, where it co-localizes with IFT trains and is required for the addition of dynein arms to the distal end of the flagellum
    • basic FUNCTION
  • play likely a role in intraflagellar transport (IFT)-dependent assembly of outer row dynein arms, not axonemal docking
  • plays likely an important role in formation and transport of mature dynein complexes during flagellar assembly
  • having a likely role in dynein transport during cilia assembly that is evolutionarily important for cilia motility
  • recruited during flagellar assembly before its removal during flagellum maturation, after cell division
  • likely performs an IFT-associated function in motile cilia
  • potential role for LRRC56 in the assembly of dynein arms in the distal portion of the axoneme
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC56 interacts with the intraflagellar transport (IFT) protein IFT88
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS41
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS