| basic FUNCTION
| involved in the maintenance of elastic fibers and anchoring epithelial cells to the interstitial matrix |
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with FBN2, regulate lung fibroblast migration  |
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glycoprotein component of the extracellular microfibrils |
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FBN1 and FBN2, the structural components of extracellular microfibrils, differentially regulate TGFbeta and bone morphogenetic protein (BMP) bioavailability in bone |
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FBN2 exerts a greater positive influence on the mechanical properties of bone than FBN1 assemblies, and the above findings are mostly, if not exclusively, related to the differetial control of TGFbeta family signaling by fibrillin proteins 2) |
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both FBN1 and FBN2 are essential for the formation of thick oxytalan fibers in the ciliary zonule and are informative for clarifying the mechanism of homeostasis of the ocular matrix |
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FBN1, FBN2, FBN3, are important in maintaining the structure and integrity of the extracellular matrix and, in combination with their sequence family members the LTBPs, also contribute to the regulation of the TGFB family of major growth factors |
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both FBN1 and FBN2 expression is required to form thick oxytalan fibers in the periodontal ligament (PDL) |
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FBN1 regulates mesenchymal stem cells [MSCs] activity by modulating TGFB1 bioavailability within the microenvironment of marrow niches |
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FBN1-microfibrils influence adult bone marrow hematopoiesis |
