Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KPNA7 contributors: mct - updated : 23-10-2018
HGNC name karyopherin subunit alpha 7
HGNC id 21839
Corresponding disease
SICACCH infantile spasms, cerebellar abnormalities, corpus callosum hypoplasia
Location 7q22.1      Physical location : 98.771.196 - 98.805.089
Synonym name
  • importin subunit alpha-8
    • Synonym symbol(s) IPOA8
    DNA
    TYPE functioning gene
    STRUCTURE 73.95 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1712 - 516 - 2014 24275456
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to KPNA2
    Homologene
    FAMILY karyopherin alpha nuclear importer family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • predominantly nuclear distribution under steady state conditions
    • basic FUNCTION
  • nuclear import proteins that recognize and bind nuclear localization signals (NLSs) in proteins to be transported to the nucleus
  • functional role for KPNA7 in human cancer
  • contribution of KPNA7 to the regulation of cancer cell growth and the maintenance of nuclear envelope environment
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • could be specialized for interactions with select NLS-containing proteins, potentially impacting developmental regulation
  • KPNA7 interaction was confirmed for MVP and ZNF414, with distinct roles as novel regulators of pancreatic cancer cell growth
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SICACCH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of pancreatic cancer cell lines and acts as a critical regulator of growth in these cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS