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FLASH GENE

Symbol

PPCS

contributors: mct - updated : 13-07-2018

HGNC name	phosphopantothenoylcysteine synthetase
HGNC id	25686

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CMD1PP dilated cardiomyopathy 1PP
Location	1p34.2      Physical location : 42.922.172 - 42.926.085
EC.number	6.3.2.5

DNA

TYPE	functioning gene
STRUCTURE	17.04 kb

MAPPING

cloned

linked

status

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001287507 3 - 2108 NP_001274436 - 105 - 2009 19683078 NM_001287506 3 - 1891 NP_001274435 - 138 - 2009 19683078 NM_001287511 3 - 958 NP_001274440 - 244 - 2009 19683078 NM_001287510 2 - 2485 NP_001274439 - 138 - 2009 19683078 NM_024664 3 - 2312 NP_078940 - 311 - 2009 19683078 NM_001287508 3 - 1963 NP_001274437 - 138 - 2009 19683078 NM_001077447 3 - 1867 NP_001070915 - 138 - 2009 19683078 NM_001287509 3 - 1822 NP_001274438 - 138 - 2009 19683078

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzes the formation of phosphopantothenoylcysteine from (R)-phosphopantothenate and L-cysteine with the concomitant consumption of a nucleotide triphosphate
	catalyzes the second step of the pathway during which phosphopantothenate reacts with ATP and cysteine to form phosphopantothenoylcysteine
	is the second enzyme of the CoA de novo biosynthesis pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMD1PP

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS